A newsletter for those involved in clinical trials. Published 20 times a year by Canary Ltd

Placebo in trials

The following articles on this topic have been published in CRAdvisor (CRA) – the year, issue number and starting page number for each are listed below:

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2005  
CRA 2005; 161:7 Avoiding failure in Phase III.
   
2004  
CRA 2004; 136:9 Recruitment can be a major ethical problem in the less developed world.
   
2003  
CRA 2003; 102:1 WHO updates international ethical guidelines for clinical studies.
CRA 2003; 104:6 Ethical use of placebo.
CRA 2003; 114:5 Will a new Declaration of Helsinki solve the debate on placebo-controlled trials?
CRA 2003; 117:1 Lawsuits issued to investigators, study co-ordinator ,hospital, sponsor and IRB.
   
2002  
CRA 2002; 82:1 Will Helsinki be revised in 2002?
CRA 2002; 90:4 Declaration of Helsinki - which version?
CRA 2002; 100:6 World Medical Association's Declaration of Helsinki.
CRA 2002;100:12 Overview of documents produced by the ICH process.
   
2001  
CRA 2001; 66:6 Sponsors react to FDA sham controls.
CRA 2001; 68:3 Special report from Pretoria 2001 - interpreting and implementing Helsinki 2000.
CRA 2001; 71:1 WMA may be forced to change Helsinki 2000.
CRA 2001; 73:1 EMEA releases opinion on placebo trials.
CRA 2001; 73:4 EMEA/CPMP position statement on the use of placebo in clinical trials with regard to the revised Declaration of Helsinki.
CRA 2001; 79:1 WMA clarifies Helsinki placebo problem.
   
2000  
CRA 2000; 56:1 New Declaration of Helsinki approved.
CRA 2000; 57:3 Use of placebo still major cause of ethical unrest.
   
1998  
CRA 1998; 3:1 Justifying the use of placebo: regulations versus ethics.
CRA 1998: 3:3 Ethical principles and the use of placebo.

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