A newsletter for those involved in clinical trials. Published 20 times a year by Canary Ltd

Patient protection

The following articles on this topic have been published in CRAdvisor (CRA) – the year, issue number and starting page number for each are listed below:

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2007  
CRA 2007; 187:6 CDER warning letters highlight investigator failings.
CRA 2007; 188:6 Prisoner research in the USA.
CRA 2007; 188:7 IRB fails to provide adequate subject protection.
CRA 2007; 190:8 New report on protecting subjects.
   
2006  
CRA 2006; 168:2 TeGenero monoclonal antibody causes shock side-effects in UK trial.
CRA 2006; 174:2 No compensation for injured research subjects in the USA?
CRA 2006; 174:3 New FDA initiative aims to modernise clinical trial regulation and bioresearch monitoring.
   
2005  
CRA 2005; 144:7 Problems with Cox-2s cause public alarm.
CRA 2005; 151:1 FDA inspector unimpressed by explanation for serious trial violations.
CRA 2005; 155:2 Inspection reveals trial commenced without IND.
CRA 2005; 156:8 Common rule amendments.
CRA 2005; 160:4 Identifying the most frequent violations of FDA regulations.
   
2004  
CRA 2004; 123:3 Improving best practices: FDA warnings to sponsors reveal significant defects.
CRA 2004; 132:3 New guidance to protect trial subjects from financial conflicts of interest.
CRA 2004; 133:1 What is the impact of EU Directive 2001/20/EC on clinical research?
CRA 2004; 137:11 WMA supports smoke-free public places.
CRA 2004; 138:1 US guidance on the use of clinical holds following misconduct at site.
CRA 2004; 138:2 How to comply with the 'Common Rule' - or not as the case may be!
CRA 2004; 138:8 DIA identifies key issues for subject protection.
CRA 2004; 140:3 The use of clinical holds following investigator misconduct.
   
2003  
CRA 2003; 108:1 US proposes new guidance for financial conflicts of interest in human subject research.
CRA 2003; 113:2 Shake up for Veterans Affairs research.
CRA 2003; 117:6 Veterans Affairs developments.
CRA 2003; 119:2 Human subject protection regulations and the 'Common Rule'.
   
2002  
CRA 2002; 82:1 FDA detachment may harm subjects in foreign trials.
CRA 2002; 85:6 Consortium for subject protection. 
CRA 2002; 96:1 New final version of US 'Privacy Rule'.
CRA 2002; 96:2 How US 'Privacy Rule' affects industry sponsors.
CRA 2002; 99:2 New approaches to subject protection in USA.
CRA 2002; 99:6 Crisis management.
CRA 2002; 100:6 An overview of US regulations contained in the Code of Federal Regulations.
   
2001  
CRA 2001; 62:1 Does a patient always get the best proven treatment?
CRA 2001; 63:4 Patient protection procedures to be revised.
CRA 2001; 67:3 Early termination of studies may harm subjects.
CRA 2001; 68:2 Helsinki article 30 caused problems for trial sponsors.
CRA 2001; 80:8 National award program to promote subject protection.
   
2000  
CRA 2000; 51:6 New patient protection strategies in USA.
CRA 2000; 53:2 Content of the latest draft of the Directive on GCP in Clinical Trials.
   
1999  
CRA 1999; 24:5 Member States must define protection for vulnerable subjects.
CRA 1999; 24:6 Extension for Ethics Committee review to be reduced from 30 to 15 days? (Subject protection in trials stopped early.)
CRA 1999; 32:1 Compensation rights - are patients aware?
   
1998  
CRA 1998; 8:1 Patients will need independent trial information.

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